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Objective To investigate the clinical significance of prostate specific antigen density (PSAD)value in the differential diagnosis from malignant and benign prostate disease .Methods 56 patients who enrolled in this hospital during April 2008 to No-vember 2012 were reviewed ,all of them were suspected as prostate carcinoma with free total PSA value at 4-10 ng/mL .Prostate volume were determined via transrectal ultrasound ,while serum PSA was determined by chemiluminescence method ,and all patients were finally pathologically diagnosed via tissue biopsy or prostatectomy .21 cases were proved to be prostate carcinoma (prostate carcinoma group) ,and the other 35 cases were proved to be benign prostate hyperplasia(BPH) .And the statistical significances of tPSA ,prostate volume and PSAD values were compared between the two groups .Results Compared with BPH group ,serum level of tPSA was insignificant ,while the values of prostate volume and PSAD were significantly lower in the BPH group than in prostate carciboma group .Considering the mean prostate volume(39 .27 mL) as the reference point ,40 mL was set as the cut-off value of prostate volume .Therefore ,there were 80 .95% prostate carcinoma group patients whose prostate volume were less than 40 mL , and 68 .57% benign prostate hyperplasia group patients whose prostate volume were larger than 40 mL .Considering the PSAD val-ue(0 .147) as the reference point ,0 .15 was set as the cut-off value of PSAD .Therefore ,the sensitivity ,specificity ,positive predic-tive value and negative predictive value among patients with prostate volume less than 40 mL ,the datas were respectively as 80 .95% ,72 .73% ,85% and 61 .54% .While ,among patients with prostate volume larger than 40 mL ,were respectively as 75% , 66 .67% ,27 .27% and 94 .11% .Conclusion PSAD was of certain value in the differential diagnosis of prostate carcinoma in PSA gray zone cases .If PSAD=0 .15 was consider as the cut-off point ,the sensitivity and specificity of differential diagnosis for prostate carcinoma decreased as the prostate volume increase .However ,the influencing factors are still to be elucidated .
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Objective To investigate and analyze the dwarf reasons for children in the area of Huai'an city,Jiangsu province.Methods A retrospective analysis of 92 cases of children with short stature in our hospital in recent 5 years had been made.Results The dwarf reasons for the 92 cases of undersized children were:lack of growth hormone (53.3％),physical sexual puberty delay (16.3％),hypothyroidism (9.8％),turner syndrome (7.6％),nanosoma essentialis (5.4％),familial short stature (4.3％),intrauterine growth retardation (2.2％)and glycogen storage disease type Ⅰ (1.1％).Conclusion The main dwarf reasons for children were growth hormone deficiency and physical sexual puberty delay,and medical treatment should be used as soon as possible.
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Objective To understand the relationship among junior college students' anxious status in testing and studying behaviors and studying result. Methods TAS anxiety scale was used for the evaluation of anxious status, and data were analyzed by SPSS software. Results Statistical significance was observed among different specialties. Sex, socioeconomic status and living environment did not affect TAS score. The higher the anxious status was, the worse the studying results will be. The anxious status was associated with some studying behaviors. Conclusions Anxiety was correlated with specialities and studying behaviors, and affected studying result.
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Objective To investigate lead pollution of tap in market. Methods 16 taps (2 PPR taps and 14 metal taps)were collected and were sunk in distilled water for 4 hours,8 hours and 12 hours. Lead levels in the distilled waters were determined by atomic absorption spectrometry. Results No lead was detected for PPR taps. Of 14 metal taps,only one tap was not observed lead pollution. The top lead level was 56.54 ?g/L,the median was 5.79 ?g/L. These brass taps resulted in higher lead pollution than those taps with ceramic preformed core (P0.05). 72.2% of the samples with brass preformed core exceeded 10 ?g/L and only 9.5% for those taps with ceramic preformed core. These taps with registered trade mark had a slighter lead contamination than those without registered trade mark(P
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<p><b>OBJECTIVE</b>To discuss the value of P53mt and BCL-2 proteins in screening skin carcinoma due to arseniasis.</p><p><b>METHODS</b>P53mt and BCL-2 proteins were detected by immunohistochemical staining. chi(2) test was used to analyze the difference of positive rate between two groups. Screening value of the two biomarkers was also evaluated through the analysis of relative indexes.</p><p><b>RESULTS</b>Positive percentages of P53mt and BCL-2 in carcinoma group were 88.89% and 94.44% respectively, both were higher than those of 36.0% and 66.0% in non-carcinoma group (for P53mt, P < 0.01; for BCL-2, P < 0.05). ORs of P53mt and BCL-2 were 14.22 (2.93 - 68.97) and 8.76 (1.07 - 71.51), respectively. Youden's Index and specificity of P53mt were 0.529 and 64.0%, which were much higher than those of BCL-2. Serial tests improved the value of screening with Youden's Index 0.569, but parallel test lowered it to 0.244.</p><p><b>CONCLUSIONS</b>P53mt and BCL-2 were practical biomarkers to screen skin carcinoma due to arseniasis, and the former was better than the latter. The value of screening can be improved by a series of tests.</p>
Subject(s)
Humans , Arsenic Poisoning , Immunohistochemistry , Mass Screening , Proto-Oncogene Proteins c-bcl-2 , Metabolism , Skin , Chemistry , Pathology , Skin Neoplasms , Diagnosis , Metabolism , Tumor Suppressor Protein p53 , MetabolismABSTRACT
Objective To investigate lead pollution of drinking water stagnated in household pipe and its characteristic, and provide the scientific basis for safe and health consumption of drinking water. Methods 30 taps in households were randomly chosen as objects. According to the stagnated time the water samples were divided into group A (12-13 hours), group B (7-8 hours) and group C (3-4 hours). The samples were collected in 0 min, 1 min and 2 min after opening taps. Lead levels in the samples were determined by atomic absorption spectrometry (AAS), whose comparative analysis was performed by SPSS software. In total, 320 samples were analyzed. Results In group A, lead concentrations (geometric mean, the same for latter) of water samples in 0 min, 1 min and 2 min were 61.33, 12.27and 5.47 ?g/L respectively, but they were 33.90, 9.13 and 4.59 ?g/L in group B,and 11.37, 6.29 and 4.27 ?g/L in group C. There were significant differences among three groups (P